Identifying Alternative Cells Involved in SCS Therapy Featured

3:45 PM - 5:15 PM Friday, January 14

While the mechanisms of action of neuromodulation devices, in particular Spinal Cord Stimulators have been historically connected with the Gate Control theory (Wall and Melzack, 1965), recent technological advances have been challenging this statement. For few years now, Sub-perception SCS in various forms, including burst and higher frequencies, has been thoroughly discussed at Neuromodulation conferences. More recently, emerging research, based on preclinical animal data as well as complex computational modeling and algorithms, has started clinical validation of new SCS mechanisms of action exploring the roles of surround inhibition neurons as well as that of glial cells as they interact with the pain neural network. Physicians and scientists in the Neuromodulation space need to understand these new SCS mechanisms in order to inform further research and create robust and reproducible patients' plans of care based on true evidenced based research.

Learning Objectives

Upon completion of this educational activity, participants should be able to:

  • Understand the novel, emerging mechanisms of action in neuromodulation
  • Describe role of preclinical research in supporting new mechanistic research
  • Describe role of computational modeling in supporting new mechanistic research
  • Describe the scientific basis for surround inhibition neuron activation and differential therapy multiplex as mechanism of action for neuromodulation