In recent years, there has been an increasing interest to understand and construct structural-functional brain maps using diffusion sensitized imaging and BOLD fMRI in neuromodulation. These neuroimaging biomarkers can help to establish an understanding of neurological basis for monitoring symptoms while implementing longitudinal management of disease progress in people with neurological disorders (epilepsy, tumor, Parkinson and so on) for routine care, rehabilitation, or in experimental therapeutic treatments. This will lead surgeons to individualize treatments for these patients. This session will examine the use of advanced neuroimaging techniques such as BOLD fMRI, DTI and tractography in conjugation with neuromodulation to better understand the therapeutic mechanism of brain stimulation. The ultimate aim of this session is to better understand how impaired functional and structural subnetworks contribute to neurological and psychiatric symptoms, and use this information to stratify optimum targeted therapies using noninvasive brain stimulation techniques.
Upon completion of this educational activity, participants should be able to:
- Describe the underlying physical basis and fundamentals of functional and physiological imaging techniques such as BOLD fMRI, Diffusion Tensor Imaging, and Tractography.
- Explain the clinical applications and limitations of functional and physiological imaging, as well as functional-structural connectomes with the focus in neuromodulation.
- Illustrate a practical step-by-step post-processing of BOLD fMRI and DTI and navigation of this information into stereotactic pre and intra operative surgical planning environments.
- Discuss how to effectively integrate functional-structural brain mapping into routine clinical practice by knowing the potential barriers and limitations.
DTI: Basics and Applications in Neuromodulation
Nader Pouratian, MD
BOLD fMRI: Basics and Applications in Neuromodulation
Scott Faro, MD
Image Processing and Analysis: DTI and fMRI
Mahdi Alizadeh, PhD
Connectomics in Neurological Disorders
Dario J. Englot, MD PhD
Faculty and Presentations subject to change.