This session will focus on the current state-of-art about the mechanisms of action underlying neuromodulation in providing therapeutic efficacy. Speakers will present current knowledge on various modalities of neuromodulation involving electrical deep brain stimulation to non-invasive ultrasound and their ability and scope to alter expression and/or activity of substrates spanning molecules, cells to neural circuits. The information will help to provide a more comprehensive perspective about affected substrates from neuromodulation. Knowledge arising from this synopsis can be leveraged to optimize, personalize and/or further innovate neuromodulation efficacy.
Upon completion of this educational activity, participants should be able to:
- Explain how neuromodulation affects gene and protein expression.
- Describe how different cell types are affected by neuromodulation.
- Indicate the difference in mechanism of action between electricity and ultrasound modulation.
- Identify the effects of neuromodulation on whole brain activity.
Modeling the Effects of Deep Brain Stimulation Parameters on Fibers and Cell Bodies
Cameron McIntyre, PhD
Effects of Ultrasound on Brain Function
Jan Kubanek, PhD
Deep Brain Neuromodulation Alters Gene Expression
Lili-Naz Hazrati, MD PhD FRCPC
Optical Imaging of the Neural Response to Electrical Stimulation in the Brain
Takashi DY. Kozai, PhD
Faculty and Presentations subject to change.